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De Novo DNA

Design Software & Services for Engineering Organisms

Predict. Control. Design. Optimize.

Predicting and Controlling Transcription & Translation Rates

Predict & Control Protein Expression Levels

Calculate transcription rates, translation rates, and mRNA decay rates across your system. Find cryptic promoters and mis-annotated coding sequences. Design synthetic promoters and ribosome binding sites with desired protein expression levels.

Design & Optimize Metabolic Pathways

Systematically vary and optimize enzyme expression levels. Find the rate-limiting steps. Redirect metabolic fluxes. Maximize organism productivities.

Design and Optimization of a Metabolic Pathway

Mazzively Parallel Protein Libraries

10 to 10000 Proteins. $100 per Cloned Expression Plasmid.
Any Amino Acid Sequence
(up to 900 amino acids)
For bioprospecting, biologics development, enzyme engineering & much much more.

Promoter Calculator
RBS Calculator
RBS Library Calculator
Operon Calculator
and more


Registered Researchers


Designed Genetic Systems



Our Team

Photo of Anna Chan-Salis
Anna Chan-Salis

Research Scientist. Molecular Biology & Biochemistry.
Genomics. Next-gen Sequencing.

Photo of Howard Salis
Howard Salis, Ph.D.

Chemical Engineer. Synthetic Biologist.
Software developer. Entrepreneur. Professor.

Photo of De Novo DNA's laboratory'

Published Applications

Contact Us

200 Innovation Blvd. Suite 239. State College, PA. 16803